[53] Supplier: UmbroSponsor(s): Hamptons Floor Store (Front of Jersey) Source: [52] Key: H = Home, A = Away, N = Neutral Damien Duff was announced as manager for the 2022 season on 3 November 2021.

[54] Defender Ally Gilchrist was announced as a new signing for Cork City on 5 November 2021 on the same day that striker Michael O'Connor was released after one season at Tolka Park.

[33] New Zealander Adam Thomas was signed on 15 February 2022 after training with the squad during the close season, and defender Michael Barker was confirmed as having joined Longford Town on 17 February 2022[28][50] Hours before the season opener against St Patrick's Athletic it was announced that Shelbourne had met with the Dublin City Council to propose purchasing Tolka Park and redeveloping it into a multi sport stadium.

[65] A sell out crowd of 4,100 at Tolka Park saw 9 new players line up for Shels with Luke Byrne and John Ross Wilson the only starters from the 2021 squad.

[69] The remainder of March saw Shels draw 1–1 with both Dundalk and Bohemians before losing 0–3 at home to bottom club Finn Harps ahead of the first season break.

Shels welcomed Sligo Rovers the following day and ran out 2-1 winners with a first goal for Jack Moylan and a fourth of the season for Sean Boyd securing the win.

[81] A defeat away to Shamrock Rovers saw Shels retain their 6th position in the league table on the same day that Shane Farrell signed a contract extension which secured his services for the 2023 season.

[83][84] Jordan McEneff also returned to his parent club in the same week as Welsh goalkeeper Scott Van Der Sluis joined and JJ Lunney extended his contract until 2023.

[86] Jad Hakiki's services were secured with a contract extension until 2024 on 30 June 2022, with Brian McManus being signed to 2023 soon after[10][5] An away defeat to Sligo Rovers was followed by 3–1 win at home over Finn Harps, helping the team maintain 7th position in the league.