The 2022 East Carolina Pirates football team represented East Carolina University during the 2022 NCAA Division I FBS football season.

The Pirates played their home games at Dowdy-Ficklen Stadium in Greenville, North Carolina, and competed as members of the American Athletic Conference.

They were led by head coach Mike Houston, in his fourth season.

[1] East Carolina signed 18 players in the class of 2022.

Sources: The Pirates will host the three of their non-conference opponents, NC State from the ACC, Old Dominion from Conference USA and Campbell from Division I FCS.