The 2022 Campeonato Ecuatoriano de Fútbol Serie B, known as the LigaPro Betcris Serie B 2022 for sponsoring purposes,[1] was the 64th season of the Serie B, Ecuador's second tier football league, and the fourth under the management of the Liga Profesional de Fútbol del Ecuador (or LigaPro).
The season began on 15 March and ended on 30 October 2022.
LDU Portoviejo and Atlético Porteño were relegated after finishing in the bottom two places of the aggregate table of the previous season, being replaced by the 2021 Segunda Categoría champions Libertad and runners-up Imbabura.
Manta and Olmedo were relegated after finishing in the bottom two places of the aggregate table of the 2021 Serie A.
[4] To preserve chronological evolvements, any postponed matches were not included to the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.