Liga Deportiva Universitaria de Quito's 2022 season was the club's 92nd year of existence, the 69th year in professional football, and the 61st in the top level of professional football in Ecuador.

Supplier: Puma Sponsor(s): Banco Pichincha, Mazda, Universidad Indoamérica, Discover, Pilsener, Ecuabet, Salud SA

Note: Caps and goals are of the national league and are current as of the beginning of the season.

Quito qualified to the 2022 CONMEBOL Sudamericana—their 13rd participation in the continental tournament—as 6th place in the 2021 LigaPro.

Note: Players in italics left the club mid-season.