The 2022 Energy X-Prix (formally the 2022 Uruguay Natural Energy X-Prix) was an Extreme E off-road race that was held on 26 and 27 November 2022 near José Ignacio, Maldonado Department, Uruguay, about 25 km east of the seaside city of Punta del Este.

It was the fifth and final round of the electric off-road racing car series' second season, and also marked the first running of the event.

Abt Cupra XE won its first X-Prix with Nasser Al-Attiyah and Klara Andersson.

They were followed by Neom McLaren Extreme E, who visited the podium for the first time, and X44 Vida Carbon Racing's Sébastien Loeb and Cristina Gutiérrez.

This third place, combined with the 5 extra Super Sector points, granted Lewis Hamilton's team both the drivers' and the teams' titles ahead of reigning champions Rosberg X Racing.