The game, the sixth Heritage Classic, was held on March 13, 2022, between the Buffalo Sabres and the Toronto Maple Leafs at Tim Hortons Field in Hamilton, Ontario.

[1] After falling behind 2–1, the Sabres scored four unanswered goals to defeat the Maple Leafs, 5–2.

Hamilton, Ontario, was chosen due to its location in the Golden Horseshoe midway between Buffalo and Toronto.

The 2022 Heritage Classic was the lowest attended NHL outdoor game with 26,119 spectators.

[3] This game marks the first time that the bilingual version of O Canada was sung at the Heritage Classic.