General elections took place on November 8, 2022, throughout the US state of Indiana.

Incumbent Todd Young confirmed that he would run for re-election.

In 2021, Republican Holli Sullivan was appointed to the 62nd secretary of state of Indiana by Governor Eric Holcomb.

[1] Incumbent Republican state treasurer Kelly Mitchell was ineligible to run for re-election for a third term in office due to term limits.

[2] She ran against Democratic ZeNai Brooks[3] and Libertarian 2018 candidate John Schick.