The 2022 Iowa State Cyclones football team represented Iowa State University in the 2022 NCAA Division I FBS football season.

The Cyclones played their home games at Jack Trice Stadium in Ames, Iowa, and competed in the Big 12 Conference.

They were led by seventh-year head coach Matt Campbell.

[2] Listed in the order that they were released 2022 Preseason All-Big 12 teams Source:[4] Iowa State and the Big 12 announced the 2022 football schedule on December 1, 2021.

[5][6] at Jack Trice Stadium • Ames, IA at Kinnick Stadium • Iowa City, Iowa at Jack Trice Stadium • Ames, IA at Jack Trice Stadium • Ames, IA at David Booth Kansas Memorial Stadium • Lawrence, KS at Jack Trice Stadium • Ames, IA at Darrell K Royal–Texas Memorial Stadium • Austin, TX at Jack Trice Stadium • Ames, IA at Jack Trice Stadium • Ames, IA at Boone Pickens Stadium • Stillwater, OK at Jack Trice Stadium • Ames, IA at Amon G. Carter Stadium • Fort Worth, TX Quarterback Running back Wide receiver Tight end Punter Kicker Deep Snapper Offensive line Defensive line Linebacker Defensive back Legend Big 12 Defensive Player of the Year-Honorable Mention All totals via Sports Media Watch.