The Cardinals played their home games at Jim Patterson Stadium as a member of the Atlantic Coast Conference.

They were led by head coach Dan McDonnell, in his sixteenth year at Louisville.

The Cardinals advanced to the NCAA Super Regional where they fell to Texas A&M.

[2] The 2021 Louisville Cardinals baseball team finished the season 28-22, missing the NCAA Tournament for the first time since 2011.

This article relating to a baseball season is a stub.