The Grand Prix returns to Malaysia after absences in 2020 and 2021 in response to the COVID-19 pandemic.

[1] In the MotoGP class, Tetsuta Nagashima continues to replace Takaaki Nakagami in the LCR Honda, given the latter's finger injury from which he has not recovered.

In the Moto2 class, Zonta van den Goorbergh missed the round after suffering a broken left wrist during FP1 of the Australian race.

Jorge Navarro also missed the round after suffering a fractured femur during the Australian race.

In the Moto3 class, Nicola Carraro continues in his substitution in the QJmotor Avintia Racing Team against the injured Matteo Bertelle.