The 2022 Mercan'Tour Classic Alpes-Maritimes was the second edition of the Mercan'Tour Classic Alpes-Maritimes road cycling one day race, which took place in the titular department in southeastern France on 31 May 2022.

It was rated as a category 1.1 race on the 2022 UCI Europe Tour.

[2] The race was won by Dane Jakob Fuglsang (Israel–Premier Tech), which was his first win since the 2020 Il Lombardia.

[3][4] Teams could enter up to seven riders each, but many decided not to do so.

Four teams (AG2R Citroën Team, Intermarché–Wanty–Gobert Matériaux, Movistar Team, and Global 6 Cycling) fielded only six riders each, St. Michel–Auber93 only fielded five, while the remaining teams fielded the maximum number allowed.