Due to security problem, all matches have to be played in a centralised venue, which is the Thuwunna Stadium in Yangon.

After almost two years of domestic football absence in Myanmar, the league made a surprise return.

It consisted of the ten teams that were scheduled to participate in the 2021 Myanmar National League, which was cancelled due to the virus and subsequent protests.

Yangon United won 2–0 with goals from La Min Htwe and new signing Htet Phyo Wai.

In the fourth match, GFA narrowly lost to Myawady by a scoreline of 4–2, with Thet Wai Moe, Kaung Si Thu and Ye Moe Yan scoring, with the addition of a surprise Tun Nanda Oo penalty.

Rakhine United could count themselves unlucky after a late goal scored by Kaung Si Thu for Myawady.

Four goals from La Min Htwe and one from Zaw Win Thein got the Lions back on track.

Two big matches played out, as Ayeyawady held ISPE to a goalless draw, and Mark Sekyi scored in a win for Shan United against Myawady.

Khin Kyaw Win's goal against Mahar United secured ISPE three more points, Yadanarbon eased past Myawady and the two bottom teams faced off: Rakhine United and GFA, with GFA being victors after a late goal from Than Toe Aung.

Rakhine United signed multiple foreign players including Dylan Santiago, Conde Mamoudou, Ibrahim Kasule and Hiroya Radonjic.

Myo Zaw Oo scored the opening goal, but it was cancelled off by Kyaw Zin Lwin.

Kyaw Phyo Wai and Junior scored their first goals for Yangon United in a win over GFA, and Week 9 ended with Yadanarbon overwhelming ISPE 3–1.

Yan Kyaw Htwe continued his strong goalscoring form alongside a goal from Aung Naing Win.

GFA lost 3–1 to ISPE, while Ayeyawady United defeated Yadanarbon with some controversy surrounding the match.

Myanmar national team head coach Antoine Hey had called up 25 players for friendly matches in Hong Kong, in which they lost one and drew one.

Thet Naing scored the operner but it was later cancelled out by Zin Min Tun in the 25th minute for a 1–1 draw.

ISPE and Mahar United shared points and Yadanarbon won against a winless Myawady side in multiple matches.

An 8-goal game saw Ayeyawady defeat GFA 5–3, and Hantharwady continued their great form in a win against Myawady.

ISPE defied odds in a 2–1 win against Yadanarbon, and Myawady finally won a match after four consecutive losses.

Myat Kaung Khant scored a long-range goal, and Si Thu Aung finished the match off with a penalty to secure the title.

Shan United were given a standing ovation by GFA whom they defeated 2–0 with goals from Si Thu Aung.

Another Myanmar National League match was played between two fierce rivals: Yadanarbon and Yangon United.