2022 National League Wild Card Series

The lowest-seeded division winner, and three wild card teams (each seeded according to regular season record), will play in this round.

The postseason structure is similar to the temporary format MLB used in 2020 due to the COVID-19 pandemic without first-round byes for the top two seeds.

[15][16] San Diego won both series against New York, defeating them 2–1 in early June and late July, for a total of 4–2.

[17] As the top two division winners (seeds by record), the Los Angeles Dodgers (111–51) and Atlanta Braves (101–61) earned a bye and home-field advantage in the NLDS.

In their lone postseason match-up, the two teams previously met in the 2011 National League Division Series, which was won by the Cardinals in five games.

The game was scoreless until the seventh inning, when Juan Yepez hit a pinch-hit two-run home run off of Jose Alvarado, who had just relieved Wheeler.

The score was still 2–0 in the top of the ninth when Cardinals closer Ryan Helsley, who had jammed fingers on his throwing hand in his previous appearance, allowed a single and two walks, then hit Alec Bohm with a 101-mph fastball, giving the Phillies their first run.

In the top of the first inning, Max Scherzer was greeted with a two-run home run by Padres first baseman Josh Bell.

Jurickson Profar's three-run homer off the right field foul pole in the fifth inning broke the game open for the Padres.

Two batters later, Manny Machado, capped the Padres' scoring with a solo home run to knock Scherzer out of the game.

Showalter called on Seth Lugo to record the final out of the game against Josh Bell, who represented the tying run at the plate with the Mets holding a 7–3 lead.

Joe Musgrove pitched seven scoreless innings of one–hit ball and Padres hitters scored six runs off of Chris Bassitt and the Mets bullpen as they advanced to the National League Division Series to face the Dodgers.