The 2022 Old Dominion Monarchs football team represented Old Dominion University during the 2022 NCAA Division I FBS football season.

The Monarchs played their home games at S.B.

It was their first football season in the Sun Belt Conference, competing in the East Division.

Previously a member of the Sun Belt until 1991, the University did not field a football team at that time, nor did the conference sponsor the sport.

The Monarchs were predicted to finish in last place in the Sun Belt's East Division.