The 2022 South Alabama Jaguars football team represented the University of South Alabama as a member of the Sun Belt Conference during the 2022 NCAA Division I FBS football season.

The Jaguars played their home games at Hancock Whitney Stadium in Mobile, Alabama.

The Jaguars were picked to finish second in the West Division.

Roster South Alabama and the Sun Belt Conference announced the 2022 football schedule on March 1, 2022.

at Kelly/Shorts Stadium, Mount Pleasant, MI No scoring plays