The season began on September 1, 2022, and ended with the 2022 Pac-12 Championship Game on December 2, 2022, at Allegiant Stadium in Paradise, Nevada.

On May 18, 2022, the NCAA Division I Council approved a rule change that gave conferences complete freedom in choosing the participants in their championship games.

[1] On that same day, the Pac-12 announced that effective immediately, the championship game would feature the top two teams in the conference standings.

[3] Oregon, Utah, and Washington finished the regular season in a 3-way tie for 2nd place.

The Utah Utes defeated Oregon Ducks 38–10 in the Pac-12 Football Championship Game.

[9] The teams and representatives in respective order were as follows: The preseason polls was released on July 28, 2022.

Below are the results of the media poll with total points received next to each school and first-place votes in parentheses.

All Pac–12 Honorable Mention (received votes from four or more members of the media): There was three coaching changes before the 2022 season.

[47] On September 18 following their loss to Eastern Michigan, Arizona State and coach Herm Edwards agreed to part ways.

Starting in 2022, the two teams with the highest conference winning percentage will face off in the championship game.

After a 48-45 victory over their home town rival, USC clinched the first spot in the conference title game.

The Pac-12 champion are also eligible for the College Football Playoff if they're among the top four teams in the final CFP ranking.

Notes: Honorable mentions Currently, the NCAA compiles consensus all-America teams in the sports of Division I-FBS football and Division I men's basketball using a point system computed from All-America teams named by coaches associations or media sources.

Honorable mention and fourth team or lower recognitions are not accorded any points.