The Padres' 3–1 victory over the Dodgers was considered a historic upset, as their 111 wins in the regular season were the fourth most in MLB history and 22 more than San Diego's 89.

The National League adopted the designated hitter full-time, a draft lottery was implemented, the postseason will expand from ten teams to twelve, and advertising patches appeared on player uniforms and helmets for the first time.

August 1: Taylor Rogers, Dinelson Lamet, Esteury Ruiz, & Robert Gasser to the Milwaukee Brewers in exchange for closing pitcher Josh Hader.

[41] August 2: MacKenzie Gore, CJ Abrams, Luke Voit, Robert Hassell, James Wood, & Jarlin Susana to the Washington Nationals in exchange for outfielder Juan Soto & first baseman Josh Bell.

[42] August 2: Eric Hosmer, Max Ferguson, & Corey Rosier to the Boston Red Sox in exchange for minor-league pitcher Jay Groome.