On March 10, 2022, MLB and the MLBPA agreed to a new collective bargaining agreement, thus ending the lockout.

[2] Despite starting the season with a 37–27 record, the Giants would go 44–54 the rest of the way, eliminating them from playoff contention after posting 107 wins the previous year.

[3] As a result, the team owners voted unanimously to lockout the players stopping all free agency and trades.

The National League will adopt the designated hitter full-time, a draft lottery will be implemented, the postseason will expand from ten teams to twelve, and advertising patches will appear on player uniforms and helmets for the first time.

Note: G = Games played; AB = At bats; R = Runs; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; BB = Walks; SO = Strikeouts; SB = Stolen bases; AVG = Batting average; OBP = On-base percentage; SLG = Slugging percentage; OPS = On base + slugging Stats in bold are the team leaders.