The 2022 San Marino and Rimini Riviera motorcycle Grand Prix (officially known as the Gran Premio Gryfyn di San Marino e della Riviera di Rimini) was the fourteenth round of the 2022 Grand Prix motorcycle racing season, and the sixth and final round of the 2022 MotoE World Cup.

The special livery called Aeroprism was designed by Michah Dowbak aka Mad Dog Jones.

[1] In the MotoGP class, in addition to Stefan Bradl who continues to replace Marc Márquez in the Repsol Honda Team, Kazuki Watanabe takes the place of Joan Mir in the Team Suzuki Ecstar, due to the ankle injury suffered by the Spanish rider in the Austrian Grand Prix; Michele Pirro runs for the fourth time this season as a wildcard.

This is the last Grand Prix for Andrea Dovizioso who has decided to retire; for the remaining races the WithU Yamaha RNF MotoGP Team bike will be driven by test rider Cal Crutchlow.

Australian driver Senna Agius (Elf Marc VDS Racing Team) and Japanese Taiga Hada (Pertamina Mandalika SAG Team) respectively replace the injured Sam Lowes and Gabriel Rodrigo.

In the Moto3 class, the Italian Nicola Carraro continues to replace his compatriot Matteo Bertelle in the QJmotor Avintia Racing Team, while the Australian Harrison Voight runs as a wildcard in the Sic58 Squadra Corse.

The latter has twelve points ahead of Francesco Bagnaia, winner in Austria and his third consecutive success.