In the MotoGP class, Enea Bastianini's win helped Ducati secure its third consecutive and fourth overall Constructors' Championship.

[1] In the MotoGP class, Marc Márquez returns to the track with the Honda of the Repsol Honda Team, who had stopped after the Italian Grand Prix and had undergone a fourth surgery on his right humerus and was replaced by Stefan Bradl.

Joan Mir returned to Suzuki after missing the Misano race due to an ankle injury sustained in the Austrian Grand Prix and replaced by Kazuki Watanabe.

In the Moto2 class, the Japanese Taiga Hada continues to replace Gabriel Rodrigo in the Pertamina Mandalika SAG Team, and the Australian Senna Agius continues to replace Sam Lowes in the Elf Marc VDS Racing Team.

The fourth consecutive success obtained at Misano (the sixth of the season) allows Francesco Bagnaia to overtake Aleix Espargaró in second place in the riders' classification (181 vs. 178 points) and to further reduce the delay from the leader Fabio Quartararo (211 points).