The 2021 San Marino and Rimini Riviera motorcycle Grand Prix (officially known as the Gran Premio Octo di San Marino e della Riviera di Rimini) was the fourteenth round of the 2021 Grand Prix motorcycle racing season and the sixth round of the 2021 MotoE World Cup, which represented the end of the season for the MotoE class.

It was held at the Misano World Circuit Marco Simoncelli in Misano Adriatico on 19 September 2021.

In this race, the Sky VR46 Team showed off a special fuchsia colored livery.

[1] Below are the standings for the top five riders, constructors, and teams after the round.

[7][8][9][10]