The 2022 Southern Miss Golden Eagles football team represented the University of Southern Mississippi as a new member of the Sun Belt Conference during the 2022 NCAA Division I FBS football season.

The Golden Eagles played their home games at M. M. Roberts Stadium in Hattiesburg, Mississippi.

The Sun Belt coaches poll was released on July 25, 2022.

The Golden Eagles were picked to finish fifth in the West Division.

[1] Special teams 2nd team Southern Miss and the Sun Belt Conference announced the 2022 football schedule on March 1, 2022.