[3] The Cardinals won the National League Central but they were upset in the NLWCS by the Philadelphia Phillies, losing in a two-game sweep.

[6] As a result, the team owners voted unanimously to lock out the players, stopping all free agency and trades.

The National League will adopt the designated hitter full-time, a draft lottery will be implemented, the postseason will expand from ten teams to twelve, and advertising patches will appear on player uniforms and helmets for the first time.

[14] He was named National League Player of the Month after having batted .375 with five home runs, 17 RBI, 12 extra-base hits and a league-leading 1.125 OPS.

[15] On May 23, Goldschmidt hit a walk-off grand slam in the bottom of the tenth inning versus the Toronto Blue Jays for a 7–3 win.

Albert Pujols became the 10th player in major league history to achieve 3,000 games played on June 4, appearing in the second inning as an injury replacement for Corey Dickerson.

They overtook the Milwaukee Brewers in the race for the National League Central division; at one point, their lead stood at 8.5 games.

In a September 8 game against the Washington Nationals, Adam Wainwright and Yadier Molina made their 324th start as a battery, tying the Major League record.

On September 23, 2022, Albert Pujols hit his 699th and 700th home runs, in a game in which the Cardinals shut out the Los Angeles Dodgers, 11-0.

Note: G = Games played; AB = At bats; R = Runs; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; SB = Stolen bases; BB = Bases on balls; SO = Strikeouts; BA = Batting average; OBP = On-base percentage; SLG = Slugging percentage; OPS = On-base percentage plus slugging; TB = Total bases Source[23] (through October 5, 2022) Players in bold are on the active roster.