Tulane defeated USC in the Cotton Bowl 46–45, scoring 16 points in the final four minutes to win the game.

[2] In the game, with 4:30 remaining and the team facing a 15-point deficit, Tulane's win probability stood at 0.2%, yet the Green Wave pulled off the incredible comeback.

[3] Following a 45–31 win against South Florida, Tulane was ranked in the AP Poll for the first time since 1998.

It was also the fastest Tulane has ever clinched bowl eligibility in school history at October 15.

[6] Listed in the order that they were released Tulane and The American announced the 2022 football schedule on February 17, 2022.