The Bearcats played their home games at Nippert Stadium and competed as members of the American Athletic Conference (AAC).

The Bearcats capped an undefeated regular season by defeating Houston in the American Conference championship game.

[3] Three Bearcat offensive lineman were named to the first team All-Conference: Lorenz Metz, Dylan O’Quinn, and Jake Renfro.

Cornerback Coby Bryant was also named to the first-team All-Conference and several All-America teams, and was the recipient of the Jim Thorpe Award.

Nine Cincinnati players were selected in the 2022 NFL draft, including fourth-overall pick Sauce Gardner.

[5][6] Darren Paige was named the new running backs coach after the departure of Dan Enos.

They travelled to Indiana of the Big Ten Conference, and to Notre Dame in their first meeting against former Bearcats head coach Brian Kelly, winning both contests.