The 2022 UAB Blazers football team represented the University of Alabama at Birmingham as a member of Conference USA (C-USA) during the 2022 NCAA Division I FBS football season.

The Blazers played their home games at Protective Stadium in Birmingham, Alabama.

During the last season, on October 21, 2021, UAB accepted the invitation to join the American Athletic Conference (AAC) and will become a full member on July 1, 2023.

On November 30, 2022 former NFL quarterback Trent Dilfer was announced as the new head coach of UAB football.

[3] UAB and Conference USA announced the 2022 football schedule on March 30, 2022.