Key: Highlighted swimmers fulfilled the qualification criteria and were named to the team roster for the 2022 World Aquatics Championships in the event.
[5][6][7][8][9] Highlighted swimmers achieved a top-two finish and the FINA "A" cut standard for the 2022 World Aquatics Championships in the event and were not named to the team roster.
[6] The following pool swimmers qualified for the United States team in at least one event for the 2022 World Aquatics Championships, held in Budapest, Hungary in June and July.
[25] The following pool swimmers achieved a spot on the United States roster in at least one event for the 2022 Junior Pan Pacific Swimming Championships.
[26][27] The following pool swimmers were each named to the roster for the 2022 Mel Zajac Junior International team representing the United States in at least one event.