[8] Their nonconference schedule complete, the Roadrunners began their C–USA slate with a road clash against Middle Tennessee, a fifteen point win.

The Roadrunners were victorious by a margin of four points, earning them their sixth win and bowl eligibility as a result.

[13] Dominant wins over Louisiana Tech[14] and C-USA regular-season title[15] vs Rice followed,[16] and UTSA closed out their regular season at home with a three-point victory over the UTEP Miners, after overcoming a 24-point deficit they faced in the game's second quarter.

There, they defeated North Texas in a rematch by three touchdowns, earning the program's second overall and consecutive conference championship.

[20] The Conference USA media day was held on July 27 at Globe Life Field in Arlington, Texas.