Despite losing the concurrent Senate and governor elections, the Republicans flipped both the 2nd and 6th congressional districts, making this the first time that the party controlled six seats in Arizona since 2004.

Schweikert narrowly defeated Democrat Jevin Hodge in what proved to be the year's closest House race in the state.

[b] O'Halleran ran for re-election and lost to Republican businessman Eli Crane.

David Giles, a perennial candidate, Tanya Contreras Wheelas, a former staffer of Arizona senator Martha McSally, and Alex Stovall, a U.S. Army veteran, were the first to announce.

In December 2021, secretly recorded conversations with Stovall dismissing his constituents and "flip-flopping" on statements he had made throughout his campaign were released.

[68] Jerone Davison, a former Oakland Raiders running back and longtime pastor in Maricopa County, launched an exploratory campaign in November 2021.

Also running were U.S. Navy veteran Rene Lopez, co-founder of Cece's Hope Center, which helps protect young women from sex trafficking, two-term Chandler City Councilman Rene Lopez, and largely self-funded businessman Kelly Cooper.

Grijalva ran for re-election and the Republican nominee, naturalized citizen and Uruguayan immigrant Luis Pozzolo, competed against him.