[1] The draw for the second qualifying round was held on 23 March 2022.
In the knockout stage, each tie will be played as a single match.
The winners, runners-up and the two best third-placed teams from the group stage will join the two participating clubs in the group stage of the 2022 AFC Champions League, Pakhtakor and Nasaf.
[6] The cup winner qualifies for a place in the 2023–24 AFC Champions League.
This article about an Uzbekistani football competition is a stub.