[2] The result was considered a historic upset by the media, as Aston had been regarded as a safe seat for the Liberals, and had been held by the party since the 1990 federal election.

[15] The by-election was quickly labelled as key for the Coalition, who were in opposition at the federal level, and had performed poorly in recent Victorian elections.

She was selected by the state party's administration committee, a decision taken to avoid the lengthy process of a members' ballot given the relatively short timeframe of the election.

[20][22][23][24] News of Tudge's resignation had also prompted speculation that former treasurer Josh Frydenberg, who lost his seat of Kooyong at the 2022 election, would seek the Liberal Party endorsement for the by-election.

[39] Simon Holmes à Court, founder of Climate 200, had expressed interest in funding a community-based teal independent if one were to run; this did not eventuate.

[41] Labor campaigned on issues including the resignation of former member Tudge, the Robodebt scandal, Peter Dutton's leadership of the Liberal party, and cost of living.

[26] The Liberal Party campaigned on issues including the rising cost of living and the withdrawal of funding to local road and transport projects under the new Albanese Labor government.

[47][48] On 27 March, Dutton sent a WhatsApp message to Pesutto saying "John for the sake of [the] Aston [by-election] could we pls put this issue to bed today.

[49] In private discussion with colleagues, Pesutto said that he could "see the feds [federal Liberal party] blaming me for Aston" so "lying low" was the best approach.

[51] David Littleproud, leader of the National Party of Australia, stated that "character assassination" of Dutton had hurt the Liberal's campaign.

[51] Littleproud also stated the Victorian Liberal Party were doing "everything they could locally there to trash their own brand" by fighting internally on whether to expel Moira Deeming.

[52] The Victorian Liberal party has preselected former mayor of the City of Knox Manny Cicchiello to be their candidate at the 2025 Australian federal election.

[53] Premier of Victoria Daniel Andrews stated that the Liberal party was "a nasty, bigoted outfit and people have worked them out, and that might be why they keep losing".