On the second attempt, the race got off to a bumpy start when Callum Ilott collided with Kyle Kirkwood at the turn 3, resulting in the first yellow flag.

The race restarted on lap 7, and Scott McLaughlin tried to regain the second position he had lost to Romain Grosjean at the start, but to no avail.

Marcus Ericsson's alternate tires started to lose performance, which was taken advantage of by Will Power and Felix Rosenqvist, who moved up to fifth and sixth place respectively.

Power continued to show great pace and made impressive moves in Turn 3, passing Scott Dixon for fourth and then overtaking McLaughlin for third.

Pato O'Ward tried to overtake Santino Ferrucci, but made a mistake and hit the wall in turn 9 on lap 44, generating the second yellow flag.

During the yellow flag, Ericsson, Conor Daly, Hélio Castroneves, Jack Harvey and Benjamin Pedersen took the opportunity to make their pit stops.

The leading drivers began to make their pit stops to change to primary tires for the final stint of the race.

The race restarted with 14 laps to go, but immediately the fifth yellow flag was displayed due to a David Malukas crash in Turn 9, on an unfortunate day for Dale Coyne.

Palou held on to the lead, while Power and Dixon got tangled up in touches, allowing Rossi to take second place.

In the midst of the madness, Rosenqvist pushed Rossi into the wall to secure third place, and Dixon took advantage of this situation to take fourth.

Alex Palou crossed the finish line as the winner of the Chevrolet Detroit Grand Prix, taking his second win of the season and his first on a street circuit in his IndyCar career.