The 2023 Copa Sudamericana final stages were played from 11 July to 28 October 2023.
Teams from the same association may play each other from the knockout round play-offs onwards.
Starting from the knockout round play-offs, the teams play a single-elimination tournament with the following rules:[2] The draw for the round of 16 was held on 5 July 2023, 12:00 PYT (UTC−4) at the CONMEBOL Convention Center in Luque, Paraguay.
Tied 4–4 on aggregate, América Mineiro won on penalties and advanced to the quarter-finals (Match S3).
Tied 3–3 on aggregate, LDU Quito won on penalties and advanced to the quarter-finals (Match S4).
Tied 1–1 on aggregate, Corinthians won on penalties and advanced to the semi-finals (Match F2).
Tied 2–2 on aggregate, LDU Quito won on penalties and advanced to the semi-finals (Match F1).