Newcastle were aiming to end one of the longest trophy droughts in English football,[5] with their last major honour being the 1968–69 Inter-Cities Fairs Cup.

[11] In the quarter-finals, Manchester United were drawn at home to EFL League One club Charlton Athletic with the match played on 10 January 2023.

Newcastle won 2–1 with goals from club captain Jamaal Lascelles and Chris Wood, after Elliott Nevitt had given Tranmere the lead.

[15] In the third round, they were drawn at home to fellow Premier League club Crystal Palace, with the match played at St James' Park on 9 November.

Will Hughes and Joel Ward converted their penalties for Palace, with club captain Luka Milivojević, Jean-Philippe Mateta and Malcolm Ebiowei all having theirs saved by Nick Pope.

[20] Back-up goalkeeper Martin Dúbravka was cup-tied due to appearing for the final opponents on loan in the earlier rounds, leaving third-choice Loris Karius to make his club debut in the showpiece.