The 2023 Iowa State Cyclones football team represented Iowa State University in the Big 12 Conference during the 2023 NCAA Division I FBS football season.

The Cyclones were led by Matt Campbell in his eighth year as their head coach.

They played their home games at Jack Trice Stadium in Ames, Iowa.

[2] [3] [4] at Jack Trice Stadium • Ames, IA at Jack Trice Stadium • Ames, IA at Peden Stadium • Athens, OH at Jack Trice Stadium • Ames, IA at Gaylord Family Oklahoma Memorial Stadium • Norman, OK at Jack Trice Stadium • Ames, IA at Nippert Stadium • Cincinnati, OH at McLane Stadium • Waco, TX at Jack Trice Stadium • Ames, IA at LaVell Edwards Stadium • Provo, UT at Jack Trice Stadium • Ames, IA at Bill Snyder Family Football Stadium • Manhattan, KS at Simmons Bank Memorial Stadium • Memphis, Tennessee