The vacancy was caused by the expulsion on 21 April 2023 of the incumbent Member of Parliament (MP), Tshekedi Khama of the BPF, following his absence from the minimum required two consecutive meetings of the same session to trigger a by-election per the Standing Orders of the National Assembly.

Prior to Ian and Tshekedi Khama's departure from the BDP, the constituency consistently voted for the party by significant margins.

[3] Tshekedi first became an MP for Serowe West in 2008 during a by-election that took place when his brother, Ian Khama, became the President of Botswana.

Following their arrest, they fled to South Africa to meet Ian, who is in self-imposed exile after evading the confiscation of illegally possessed firearms.

[5] According to Standing Order 16.2 of the National Assembly of Botswana, a Member of Parliament's (MP) seat becomes vacant if they are absent from the Assembly for two consecutive meetings during the same session without prior written permission from the Speaker: For the purposes of the Constitution it is hereby prescribed that the seat of any Member of Parliament (MP) shall become vacant if, without the leave of the Speaker obtained in writing before the end of the meetings referred to in this paragraph, that Member is absent from the Assembly for two consecutive meetings occurring during the same session.Having met the required criteria, Tshekedi Khama's seat in Serowe West was declared vacant on 21 April 2023 by the acting Speaker at the time, Pono Moatlhodi.