The team that will score more goals on aggregate over the two legs will advance to the next round.
If the aggregate score will be level, the away goals rule will be applied, i.e. the team that will score more goals away from home over the two legs will advance.
If away goals will also be equal, then extra time will not be played and the winners will be decided by a penalty shoot-out (Regulations III.
The mechanism of the draws for each round was as follows: The knockout stage will involve the 8 teams qualifying as winners and runners-up of each of the eight groups in the group stage.
The bracket of the knockout stage was determined as follows: The bracket was decided after the draw for the knockout stage, which was held on 20 February 2025, 18:00 AST (UTC+3) at the beIN Sports headquarters in Doha, Qatar.