The 2024–25 Northwestern State Lady Demons basketball team represents Northwestern State University during the 2024–25 NCAA Division I women's basketball season.

The Demons, led by fifth-year head coach Anna Nimz, play their home games at Prather Coliseum in Natchitoches, Louisiana as members of the Southland Conference.

The Southland Conference released its preseason poll on October 17, 2024.

Receiving 67 overall votes, the Lady Demons were picked to finish tenth in the conference.

[1] No Lady Demons were selected as members of a Preseason All-conference team.