The 46th South American Swimming Championships were held from 24 to 27 September in Cali, Colombia, being the second time the championships take place in Cali after 1960 as well as the seventh time Colombia hosts the competition.

All events took place at the Hernando Botero O'Byrne and Alberto Galindo pools within the Unidad Deportiva Panamericana Jaime Aparicio, except for the open water swimming events which were held at Calima Lake.

*   Host nation (Colombia)