[3] The draw for the qualifying stages was held on 19 December 2024, 12:00 PYT (UTC−3), at the CONMEBOL Convention Centre in Luque, Paraguay.
If tied on aggregate, extra time will not be played, and a penalty shoot-out will be used to determine the winner (Regulations Article 2.4.3).
[9] Tied 4–4 on aggregate, El Nacional won on penalties and advanced to the second stage (Match C4).
[9][16][17] Tied 3–3 on aggregate, Deportes Iquique won on penalties and advanced to the third stage (Match G1).
Tied 2–2 on aggregate, Alianza Lima won on penalties and advanced to the third stage (Match G1).