The 2025 Copa Sudamericana first stage will be played from 4 to 6 March 2025.
[3] The draw for the first stage was held on 19 December 2024, 12:00 PYT (UTC−3), at the CONMEBOL Convention Centre in Luque, Paraguay.
[4] For the first stage, the 32 teams involved were divided into eight pots according to their national association.
The first team drawn in each tie will host the match.
[5] In the first stage, each tie will be played on a single-leg basis, with the winner being decided in a penalty shoot-out in case of a draw after 90 minutes.