The incumbent administration is contesting the election as Team Marikina City, with representative Marjorie Ann Teodoro and her running mate Marion Andres leading the ticket as members of the National Unity Party.

Representative Stella Quimbo and former mayor Del de Guzman, affiliates of Lakas–CMD, are challenging the administration as Team Bagong Marikina.

Senator Koko Pimentel entered the race as a candidate for representative in the first district, following a failed attempt to form an alliance with the administration.

[5] Mayors for Good Governance, a group of local executives, deemed the complaints politically motivated and described Teodoro as transparent and accountable.

[8] James Patrick Cruz of Rappler has described Marikina as being under a "conjugal leadership", given the dominance of the Teodoro and Quimbo couples in local politics.

[16] Following the landslide victory of his Team MarCy coalition in 2022, Teodoro's administration has partnered with Senator Koko Pimentel and his wife, diplomat Kathryna Yu-Pimentel, in implementing projects in the city, including a health caravan in April 2024.

[17] After Teodoro filed to run in the first district for the elections to the House of Representatives, Pimentel followed suit, pitting the two together and rendering the partnership moot.

[18] In response, Teodoro clarified that Pimentel's camp left the alliance on July 28, leaving the administration without a candidate in the first district, hence his decision to contest the congressional seat there.

Media outlets, including the Philippine Daily Inquirer and the Manila Bulletin, have speculated that Representative Marjorie Ann Teodoro will run for mayor and head the administration ticket in 2025.

[22] Independent candidate Luisa Fajardo, a lawyer specializing in tribal customary law who previously advocated for federalism, is also seeking the office.

[8] Independent Annie Retes, a lawyer specializing in tribal customary law, also launched a bid for the office as the running mate of Luisa Fajardo.

The first district covers the barangays of Barangka, Calumpang, Industrial Valley Complex, Jesus de la Peña, Malanday, San Roque, Santa Elena, Santo Niño, and Tañong.

[42][43][44] Pimentel has made the revitalization of the local shoe industry and solving the city's flood issues as core messages of his campaign.

[42] Pimentel and three others filed a petition before the first division of the COMELEC to disqualify Teodoro from the contest, citing Section 78 of the Omnibus Election Code, which establishes material misrepresentation as a ground for disqualification.

[36] Perennial candidate Mauro Arce, who ran in 2019 and 2022, and Jose Jaime Enage, the chairman of advocate group Baybayin Buhayin, are also seeking election to the seat.