The 2025 season will be the San Jose Earthquakes' 43rd year of existence, their 28th season in Major League Soccer and their 18th consecutive season in the top-flight of American soccer.

[1] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

San Jose Earthquakes did not qualify for the 2025 Leagues Cup as they were not one of the top 9 teams in the Western Conference for the 2024 season.