The 20th CBRNE Command is the United States Army headquarters for defense against Chemical, Biological, Radiological, Nuclear, and high-yield Explosives (CBRNE), headquartered on the site of the defunct Edgewood Arsenal chemical weapons production facility at Aberdeen Proving Ground in northern Maryland.

[1] Its establishment consolidated a range of unique CBRNE assets from across the Army under a single operational headquarters at Aberdeen Proving Ground, Maryland.

When called upon, the command may deploy and serve as a headquarters for the Joint Task Force for Elimination of Weapons of Mass Destruction (JTF-E), as directed by the 2006 Quadrennial Defense Review.

The CBRNE Command leverages sanctuary reach back, linking subject matter experts in America's defense, scientific and technological communities with deployed elements and first responders.

In May 2007, the establishment of the CBRNE Analytical and Remediation Activity (CARA) with four remediation response teams, multiple mobile exploitation laboratories, and an aviation section, marked a key milestone in the Command’s ability to provide the Army with the full spectrum of specialized CBRNE forces and capabilities.

The command maintains a robust rapid response force for threats in the homeland, and routinely supports the President, other dignitaries, and national special security events.