The 48th Chemical Brigade is a United States Army brigade located at Fort Cavazos, Texas and subordinate to the 20th CBRNE Command.

The Brigade is tasked to discover, counter, and neutralize chemical, biological or nuclear threats.

The Brigade was activated 16 September 2007, under the command of Colonel Vance P. (Phil) Visser and CSM E. Donald Moten.

They were part of the 6615th Ranger Force which also included the 509th Parachute Infantry Battalion.

The lineage of the 2nd Chemical Battalion (CBRN) goes back to the 30th Engineer Regiment (Gas and Flame), formed in 1917.