The 21 Club, often simply 21, was a traditional American cuisine restaurant and former prohibition-era speakeasy, located at 21 West 52nd Street in New York City.

[3] After being shut down by the COVID-19 pandemic, the establishment announced in December 2020 that it would not reopen "in its current form for the foreseeable future" and was considering how to keep the restaurant a viable operation in the long term.

The club also stored the private wine collections of John F. Kennedy; Richard Nixon; Gerald Ford; Joan Crawford; Elizabeth Taylor; Hugh Carey; Ernest Hemingway; the Nordstrom sisters; Frank Sinatra; Al Jolson; Gloria Vanderbilt; Sophia Loren; Mae West; Aristotle Onassis; Gene Kelly; Gloria Swanson; Judy Garland; Sammy Davis Jr.; and Marilyn Monroe.

The bar is mentioned several times in David Niven's memoirs, Bring on the Empty Horses; he was given a job by J+C selling liquor following the end of prohibition, and went there with director John Huston on their return from the war.

[6] The prestigious International Debutante Ball, which has presented many daughters and granddaughters of U.S. presidents to high society at the Waldorf-Astoria Hotel in New York City, has hosted its pre-ball parties at 21 Club.

[8] In 1985, the Kriendler and Berns families sold their interests in the restaurant to General Felt Industries, a holding company headed by Marshall S. Cogan and Stephen Swid.

[11] In 1995 it became part of Orient-Express Hotels Ltd. which in 2014 changed its name to Belmond Ltd.[citation needed] On January 24, 2009, it ended its long-standing policy of requiring men to wear neckties at dinner.

[15] In November 2021, Eater reported that former employees had been publicly protesting LVMH's decision to close the club, and that the union had been neither offered severance packages or job assurances over around a year, with terms remaining unsettled.

In the 1930s, some of the affluent customers of the bar began to show their appreciation by presenting 21 with jockeys painted to represent the racing colors of the stables they owned.