The House on 22, Rue du Général de Castelnau is an Art Nouveau building in the Neustadt district of Strasbourg, France.

The house was built from 1901 until 1903 by the architects Franz Lütke (1860–1929) and Heinrich Backes (1866–1931), who used one of the floors as their office,[2] they were professional partners from 1898 until 1907.

A very prolific duo, they built a number of other Art Nouveau houses in Strasbourg, of which several are classified as Monuments historiques as well (such as 46, Avenue des Vosges; 56, Allée de la Robertsau; 4, Rue Erckmann-Chatrian; and 24, Rue Twinger).

[3] In spite of the use of reinforced concrete,[2] the house is described as "lithe and light" (souple et léger).

[4] It has been called "probably the finest Art Nouveau apartment building in the city".