The 221st MI BN stated vision for operations includes: (1) collecting and providing relevant intelligence, security and information operations for U.S. Army, joint and combined forces; (2) leveraging national/theater/tactical equipment and capabilities of assigned personnel to provide relevant information reports to commanders at all echelons; (3) exploiting leading edge technology; and (4) meeting the challenge of today, tomorrow and the 21st Century.

In early May 2003, H Company (Long Range Surveillance) of the 221st provided 54 LRS infantrymen to the 203rd Military Intelligence Battalion (TECHINT) in support of foreign materials exploitation and WMD recovery missions.

On June 25, 2003, several LRS soldiers from the 221st were the first casualties of the technical intelligence mission in Iraq when they suffered non-life-threatening injuries from a roadside IED attack on the 203rd.

[3] In April 2010, 221st MI BN mobilized and deployed 32 Soldiers as the KFOR 13 Analytical Control Element (ACE) in support of Multinational Division – East located at Camp Bondsteel.

In December 2010, 221st MI BN mobilized and deployed 32 Soldiers as the KFOR 14 Analytical Control Element (ACE) in support of Multinational Division – East located at Camp Bondsteel.