It was the garrison of the Harbor Defenses of Portsmouth in World War II.

The 22nd CA (Harbor Defense) (HD) Regiment was active from February 1940 until broken up in March 1944 as part of an Army-wide reorganization.

[1][2] Constituted in the Organized Reserve (OR) 31 March 1924 as the 614th Coast Artillery Battalion; redesignated as the 614th Coast Artillery Regiment 19 March 1926.

On 1 September 1934 was withdrawn from the OR and allotted to the Regular Army as inactive.

Redesignated as the 22nd Coast Artillery Regiment (Harbor Defense) (HD) and regimental Headquarters and Headquarters Battery (HHB) activated 1 February 1940 at Fort Constitution, New Hampshire by reorganizing caretaker detachment of HHB 8th Coast Artillery.