When training was completed moved to North Field Tinianin the Mariana Islands of the Central Pacific Area in January 1945 and assigned to XXI Bomber Command, Twentieth Air Force.

Flew "shakedown" missions against Japanese targets on Moen Island, Truk, and other points in the Carolines and Marianas.

The squadron continued to participate in wide area firebombing attack, but the first ten-day blitz resulting in the Army Air Forces running out of incendiary bombs.

Also conducted raids against strategic objectives, bombing aircraft factories, chemical plants, oil refineries, and other targets in Japan.

It was re-equipped with RC-135 Cobra Ball/Cobra Eye aircraft to support theater and national level intelligence consumers with near real-time on-scene collection, analysis and dissemination capabilities.